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王蘭

王蘭

博士
血液腫瘤學研究組組長

郵箱: lwang@sinh.ac.cn

電話: +86-21-54923267

所屬部門: 中國科學院腫瘤與微環(huán)境重點實驗室

個人簡歷

2017－至　 今：中國科學院上海營養(yǎng)與健康研究所，研究員
2015－2016年：中國科學院上海生命科學研究院/上海交通大學醫(yī)學院 健康科學研究所，研究員
2013－2015年：美國邁阿密大學，生物化學與分子生物學系，助理教授（tenure track）
2007－2013年：美國紀念斯隆凱特琳癌癥中心博士后
2002－2007年：中國科學院上海生命科學研究院健康科學研究所，生物化學與分子生物學博士
1998－2002年：復旦大學生命科學院，生物學士

研究方向

血液腫瘤和造血干細胞的調控機制

研究內容

造血干細胞惡性轉化是血液腫瘤研究的關鍵問題，但是其機理尚不甚清楚。血液腫瘤干細胞與正常造血干細胞具有一個共同的特征：自我更新的能力，因此產生的子細胞具有增強的復制能力。增強的自我更新是血液腫瘤干細胞的一個顯著特征，新的治療策略應該特異地針對腫瘤干細胞異常的自我更新。在造血干細胞/白血病干細胞自我更新調控研究中，我們發(fā)現(xiàn)敲除DNA結合抑制蛋白Id1基因能夠阻斷造血干細胞/白血病干細胞的自我更新和白血病的形成并且Id1基因在3歲以下嬰兒急性髓系白血病形成和成人急性髓系白血病形成中分別有促進和抑制的相反作用；另外，我們發(fā)現(xiàn)了Caspase-3與細胞自噬調控關鍵信號分子ULK1，mTOR作用并促進白血病發(fā)生的機理，研究結果為臨床診斷和治療提供了新的靶點。本研究組結合動物模型和生化機制分析造血干細胞惡性轉化的分子機制，并最終把基礎科研的發(fā)現(xiàn)轉化成為癌癥診療應用成果。

代表論著（#第一作者，*通訊作者）

  1. Peng-Cheng Yu, Dan Hou, Binhe Chang, Na Liu, Chun-Hui Xu, Xinchi Chen, Cheng-Long Hu, Ting Liu, Xiaoning Wang, Qunling Zhang, Ping Liu, Yilun Jiang, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Hui Liu, Bing-Yi Chen, Shu-Bei Chen, Yong Wang, Zijuan Li, Xiya Li, Chu-Han Deng, Yi-Yi Ren, Muying Zhao,Shiyu Jiang, Roujia Wang, Jiacheng Jin, Shaoxin Yang, Kai Xue, Jun Shi, ChunKang Chang, Shuhong Shen, Peng-Cheng He, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, Lan Wang*. SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis. Developmental Cell 2024 Aug 5;59(15):1954-1971.
  2. Wu X, Wang Y, Chen B, Liu Y, Li F, Ou Y, Zhang H, Wu X, Li X, Wang L, Rong W, Liu J, Xing M, Zhao X, Liu H, Ge L, Lv A, Wang L, Wang Z, Li M, Zhang H. ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression. Advanced Science 2024 Jan;11(3):e2303555.
  3. Jia-Cheng Jin, Bing-Yi Chen, Chu-Han Deng, Jia-Nan Chen, Feng Xu, Ying Tao, Cheng-Long Hu, Chun-Hui Xu, Bin-He Chang, Yong Wang, Ming-Yue Fei, Ping Liu, Peng-Cheng Yu, Zi-Juan Li, Xi-Ya Li, Shu-Bei Chen, Yi-Lun Jiang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Yi-Yi Ren, Fan-Huan Xu, Qi Liu, Xin-Hui Huang, Juan Guo, Qi He, Lu-Xi Song, Li-Yu Zhou, Ji-Ying Su, Chao Xiao, Yu-Mei Zhang, Meng Yan, Zheng Zhang, Dong Wu, Chun-Kang Chang, Xiao Li, Lan Wang*, Ling-Yun Wu*. ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS. Science Advances 2023 Dec;9(48):eadi7375.
  4. Xie J, Sheng M, Rong S, Zhou D, Wang C, Wu W, Huang J, Sun Y, Wang Y, Chen P, Wu Y, Wang Y, Wang L, Zhou BO, Huang X, Walsh CP, Bohlander SK, Huang J, Wang X, Xu GL, Gao H, Shi Y. STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation. Leukemia 2023 Dec;37(12):2457-2467.
  5. Fei MY, Wang Y, Chang BH, Xue K, Dong F, Huang D, Li XY, Li ZJ, Hu CL, Liu P, Wu JC, Yu PC, Hong MH, Chen SB, Xu CH, Chen BY, Jiang YL, Liu N, Zhao C, Jin JC, Hou D, Chen XC, Ren YY, Deng CH, Zhang JY, Zong LJ, Wang RJ, Gao FF, Liu H, Zhang QL, Wu LY, Yan J, Shen S, Chang CK, Sun XJ, Wang L*. The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood 2023 Sep 7;142(10):903-917.
  6. Dan Liu, Chun-Hui Xu, Yan-Ting Liu, Wen Ouyang, Shao-Jian Lin, Ai-Ning Xu, Yuan-Liang Zhang, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao, Zhu Chen, Lan Wang, Sai-Juan Chen*, Jin-Yan Huang*, Zhe-Bao Wu*, Xiao-Jian Sun*. A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumor. Frontiers of medicine 2023 Jun;17(3):458-475.
  7. Roujia Wang, Youshan Zhao, Zijuan Li,Juan Guo, Sida Zhao, Luxi Song, Dong Wu, Lan Wang*, Chunkang Chang*. S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression. Acta Biochimica etBiophysica Sinica 2023 Feb 25;55(2):194-201.
  8. Xi-Ya Li, Ji-Chuan Wu, Ping Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen, Cheng-Long Hu, Ming-Yue Fei, Peng-Cheng Yu, Yi-Lun Jiang, Chun-Hui Xu, Bin-He Chang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Ying Fang, Xiao-Jian Sun, Kai Xue, Li Wang, Shu-Bei Chen, Shi-Yu Jiang, Ai-ling Gui, Ling Yang, Juan J. Gu, Bao-Hua Yu, Qun-ling Zhang*, Lan Wang*. Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma. Leukemia 2023 Jan; 37(1):164-177.
  9. Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu, Ruirui Yang, Peng-Cheng Yu, Jingyao Zhao, Ting Liu, Na Liu, Bin Shan, Qunling Zhang, Junhong Song, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Ji-Chuan Wu, Shu-Bei Chen, Yong Wang, Binhe Chang, Dan Hou, Ping Liu, Yilun Jiang, Xiya Li, Xinchi Chen, Chu-Han Deng, Yi-Yi Ren, Roujia Wang, Jiacheng Jin, Kai Xue, Ying Zhang, Meirong Du, Jun Shi, Ling-Yun Wu, Chun-Kang Chang, Shuhong Shen, Zhu Chen, Sai-Juan Chen, Xiaolong Liu*, Xiao-Jian Sun*, Mingyue Zheng*, Lan Wang*. Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia. Cell Research 2022 Dec;32(12):1105-1123.
  10. Meijuan Bai, Peijuan Cao, Yijun Lin, Pengcheng Yu, Shuo Song, Lingling Chen, Lan Wang, Yan Chen*. Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice. Front Nutr 2022;9:892435.
  11. Jinxi Li, James D Glover, Haiguo Zhang, Meifang Peng, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C Zheng, Edie I Crosse, Alexander Medvinsky, Richard A Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P Kemp, Yvonne Y W Ho, Danuta Z Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M Chernus, Katherine Neiswanger, Eleanor Feingold, David M Evans, Sarah E Medland, Nicholas G Martin, Seth M Weinberg, Mary L Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman, Lan Wang, Li Jin, Denis J Headon, Sijia Wang*. Limb development genes underlie variation in human fingerprint patterns. Cell 2022 Jan 6;185(1):95-112.
  12. Yi-Fan Zhang, Xiao-Lin Wang, Chun-Hui Xu, Na Liu, Ling Zhang, Yu-Ming Zhang, Yin-Yin Xie, Yuan-Liang Zhang, Qiu-Hua Huang, Lan Wang, Zhu Chen, Sai-Juan Chen, Robert G Roeder, Shuhong Shen, Kai Xue, Xiao-Jian Sun*. A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation. Front Cell Dev Biol 2022 Sep 7;10:992714.
  13. Fan Zhang, Qi-Yu Zeng, Hao Xu, Ai-Ning Xu, Dian-Jia Liu, Ning-Zhe Li, Yi Chen, Yi Jin, Chun-Hui Xu, Chang-Zhou Feng, Yuan-Liang Zhang, Dan Liu, Na Liu, Yin-Yin Xie, Shan-He Yu, Hao Yuan, Kai Xue, Jing-Yi Shi, Ting-Xi Liu, Peng-Fei Xu, Wei-Li Zhao, Yi Zhou, Lan Wang, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen*, Xiao-Long Zhou*, Xiao-Jian Sun*. Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell Discovery 2021;7(1):98.
  14. Kai Xue, Ji-Chuan Wu, Xi-Ya Li, Ran Li, Qun-ling Zhang, Jin-Jia Chang, Yi-Zhen Liu, Chun-Hui Xu, Jia-Ying Zhang, Xiao-Jian Sun, Juan J. Gu, Wei-Jian Guo*, Lan Wang*. Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma. Cell Death & Disease 2021;12(10):900.
  15. Dian-Jia Liu, Fan Zhang, Yi Chen, Yi Jin, Yuan-Liang Zhang, Shu-Bei Chen, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao, Lan Wang, Peng-Fei Xu, Zhu Chen, Sai-Juan Chen, Bing Li, Ai-Jun Zhang, Xiao-Jian Sun*. Setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell Discovery 2020;6:72.
  16. Bing-Yi Chen, Jun-Hong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chun-Hui Xu, Ji-Chuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang, Na Liu, Peng-Cheng Yu, Ping Liu, Li-Juan Zong, Jia-Ying Zhang, Ruo-fei Dai, Fei Lan, Qiu-Hua Huang, Su-Jiang Zhang, Stephen D Nimer, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun*, Lan Wang*. SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS. Blood 2020;35(25):2271-2285.
  17. Na Liu, Jun-Hong Song, Yang-Yang Xie, Xiao-Lin Wang, Bo-Wen Rong， Na Man，Meng-Meng Zhang, Qun-Ling Zhang, Fei-Fei Gao, Mei-Rong Du, Ying Zhang, Jian Shen, Xu Chun Hui, Cheng-Long Hu, Ji-Chuan Wu, Ping Liu, Yuan-Liang Zhang, Yin-Yin Xie, Ping Liu, Jin-Yan Huang, Qiu-Hua Huang, Fei Lan, Shu-Hong Shen, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Robert G. Roeder*, Lan Wang*, Xiao-Jian Sun*. Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis. Proc Natl Acad Sci U S A 2019;116(3):890-899.
  18. Meng-Meng Zhang, Na Liu, Yuan-Liang Zhang, Bo-Wen Rong, Xiao-Lin Wang, Chun-Hui Xu, Yin-Yin Xie, Shu-Hong Shen, Jiang Zhu, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Robert G Roeder, Fei Lan, Lan Wang*, Qiu-Hua Huang*, Xiao-Jian Sun*. Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation. Leukemia 2019;33:1822-1827.
  19. Ye Xu, Na Man, Daniel Karl, Concepcion Martinez, Fan Liu, Jun Sun, Camilo Jose Martinez, Gloria Mas Martin, Felipe Beckedorff, Fan Lai, Jing-Yin Yue, Alejandro Roisman, Sarah Greenblatt, Stephanie Duffort, Lan Wang, Xiao-Jian Sun, Maria Figueroa, Ramin Shiekhattar*, Stephen D. Nimer*. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nature Communications 2019;10(1):4925.
  20. Yuan-Liang Zhang, Jie-Wen Sun, Yin-Yin Xie, Yan Zhou, Ping Liu, Jia-Chun Song, Chun-Hui Xu, Lan Wang, Dan Liu, Ai-Ning Xu, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun*, Qiu-Hua Huang*. Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation. Cell Research 2018;28(4):476-490.
  21. Na Man, Yu-Rong Tan, Xiao-Jian Sun, Fan Liu, Guo-Yan Cheng, Sarah Greenblatt, Camilo Martinez, Daniel L. Karl, Koji Ando, Ming Sun, Dan Hou, Bing-Yi Chen, Ming-Jiang Xu, Feng-Chun Yang, Zhu Chen, Sai-Juan Chen, Stephen D. Nimer*, Lan Wang*. Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1 dependent manner. Blood 2017;129(20):2782-2792.
  22. G Cheng, F Liu, T Asai, F Lai, N Man, H Xu, S Chen, S Greenblatt, P-J Hamard, K Ando, X Chen, Lan Wang, C Martinez, M Tadi, L Wang, M Xu, F-C Yang, R Shiekhattar, S D Nimer. Loss of p300 accelerates MDS-associated leukemogenesis. Leukemia 2017;31(6):1382-1390.
  23. Jian-Ping Li, Fu-Hong He, Peng Zhang, Shi Chen, Hui Shi, Yan-Ling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen D. Nimer, Peng Yu, Qian-Fei Wang*, Ming-Jiang Xu*, Feng-Chun Yang*. Loss of Asxl2 leads to myeloid malignancies in mice. Nature Communications 2017;8:15456.
  24. Yun-Chi Tang*, Hui Yuwen, Kai-Ying Wang, Peter M. Bruno, Kevin Bullock, Amy Deik, Stefano Santaguida, Marianna Trakala, Sarah J. Pfau, Na Zhong, Tao Huang, Lan Wang, Clary B. Clish, Michael T. Hemann, Angelika Amon*. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis. Cancer Research 2017;77(19):5272-5286.
  25. Na Man, Xiao-Jian Sun, Yurong Tan, Marta Garc′?a-Cao, Fan Liu, Guo-Yan Cheng, Megan Hatlen, Haiming Xu, Ronit Shah, Nolan Chastain, Na Liu, Gang Huang, Yuan Zhou, Mengyao Sheng, Jun-Hong Song, Feng-Chun Yang, Robert Benezra, Stephen D. Nimer*, Lan Wang*. Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin. Blood 2016;127(19):2322-2326.
  26. Fan Liu, Lan Wang, Fabiana Perna, Stephen D. Nimer*. Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape. Nature Reviews Cancer 2016;16(6):359-372.
  27. Kotaro Shirakawa, Lan Wang, Na Man, Jasna Maksimoska, Alexander W. Sorum, Hyung W. Lim, Intelly S. Lee, Tadahiro Shimazu, John C. Newman, Sebastian Schr?der, Melanie Ott, Ronen Marmorstein, Jordan Meier, Stephen D. Nimer, Eric Verdin*. Salycylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife 2016;5:e11156.
  28. Megan A. Hatlen, Kanika Arora, Vladimir Vacic, Ewa A. Grabowska, Willey Liao, Bridget Riley-Gillis, Dayna M. Oschwald, Lan Wang, Jacob E. Joergens, Alan H. Shih, Franck Rapaport, Sheng-Qing Gu, Francesca Voza, Takashi Asai, Benjamin G. Neel, Michael G. Kharas, Mithat Gonen, Ross L. Levine, Stephen D. Nimer*. Integrative analysis of the mutational landscape of mouse and human AML identifies functionally relevant leukemia disease alleles. J Exp Med 2016;213(1):25-34.
  29. Lan Wang, Pierre-Jacques Hamard, Stephen D Nimer*. PARP inhibitors: a treatment option for AML? Nature Medicine 2015;21(12):1393-1394.
  30. Lan Wang*, Na Man, Xiao-Jian Sun, Yu-Rong Tan, Marta Garcia Cao, Fan Liu, Megan Hatlen, Haiming Xu, Gang Huang, Meredith Mattlin, Arpit Mehta, Evadnie Rampersaud, Robert Benezra, Stephen D. Nimer. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood 2015;126(5):640-650.
  31. Fan Liu, Guoyan Cheng, Pierre-Jacques Hamard, Sarah Greenblatt, Lan Wang, Na Man, Fabiana Perna, Haiming Xu, Madhavi Tadi, Luisa Luciani, Stephen D. Nimer*. Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest 2015;125(9):3532-3544.
  32. Xiao-Jian Sun, Na Man, Yurong Tan, Stephen D. Nimer, Lan Wang*. The role of histone acetyltransferase in normal and malignant hematopoiesis. Front Oncol 2015; 5:108.
  33. Ly P. Vu, Fabiana Perna, Lan Wang, Francesca Voza, Maria E. Figueroa, Paul Tempst, Hediye Erdjument-Bromage, Rui Gao, Si-Si Chen, Elisabeth Paietta, Tony Deblasio, Ari Melnick, Yan Liu, Xin-Yang Zhao, Stephen D. Nimer*. PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex. Cell Reports 2013;5(6):1625-1638.
  34. Xiao-Jian Sun, Zhan-Xin Wang, Lan Wang, Yanwen Jiang, Nils Kost, T. David Soong, Wei-Yi Chen, Zhan-Yun Tang, Tomoyoshi Nakadai, Olivier Elemento, Wolfgang Fischle, Ari Melnick, Dinshaw J. Patel, Stephen D. Nimer, Robert G. Roeder*. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature 2013;500(7460):93-97.
  35. Megan A. Hatlen, Lan Wang, Stephen D. Nimer*. AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches. Front Med 2012;6(3):248-262.
  36. Gang Huang*, Xing-Hui Zhao, Lan Wang, Shannon Elf, Hao Xu, Xinyang Zhao, Goro Sashida, Yue Zhang, Yan Liu, Jennifer Lee, Silvia Menendez, Youyang Yang, Xiaomei Yan, Pu Zhang, Daniel G. Tenen, Motomi Osato, James J.-D. Hsieh, Stephen D. Nimer*. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood 2011;118(25):6544-6552.
  37. Lan Wang, Alexander Gural, Xiao-Jian Sun, Xin-Yang Zhao, Fabiana Perna, Gang Huang, Megan A. Hatlen, Ly Vu, Fan Liu, Hai-Ming Xu, Takashi Asai, Hao Xu, Tony Deblasio, Silvia Menendez, Francesca Voza, Yan-Wen Jiang, Philip A. Cole, Jin-Song Zhang, Ari Melnick, Robert G. Roeder, Stephen D. Nimer*. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science 2011;333(6043):765-769.
  38. Fan Liu, Xin-Yang Zhao, Fabiana Perna, Lan Wang, Priya Koppikar, Omar Abdel-Wahab, Michael W. Harr, Ross L. Levine, Hao Xu, Ayalew Tefferi, Anthony Deblasio, Megan Hatlen, Silvia Menendez, Stephen D. Nimer*. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell 2011;19(2):283-294.
  39. Fabiana Perna, Nadia Gurvich, Ruben Hoya-Arias, Omar Abdel-Wahab, Ross L. Levine, Takashi Asai, Francesca Voza, Silvia Menendez, Lan Wang, Fan Liu, Xin-Yang Zhao, Stephen D. Nimer*. Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera. Blood 2010;116(15):2812-2821.
  40. Yi-Wen Zhang, Xiao-Xing Jiang, Qiu-Sheng Chena, Wen-Yu Shia, Lan Wang, Han-Dong Sun, Zhi-Xiang Shen, Zhu Chen, Sai-Juan Chen, Wei-Li Zhao*. Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways. Experimental Hematology 2010;38(3):191-201.
  41. Lan Wang, Gang Huang, Xinyang Zhao, Megan A. Hatlen, Ly Vu, Fan Liu, Stephen D. Nimer*. Post-translational modifications of Runx1 regulate its activity in the cell. Blood Cells Mol Dis 2009;43(1):30-34.
  42. Lan Wang, Guang-Biao Zhou, Ping Liu, Jun-Hong Song, Yang Liang, Xiao-Jing Yan, Fang Xu, Bing-Shun Wang, Jian-Hua Ma, Zhi-Xiang Shen, Sai-Juan Chen*, Zhu Chen*. Dissection of mechanism of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A 2008;105(12):4826-4831.
  43. Wei-Li Zhao#, Lan Wang#, Yuan-Hua Liu#, Jin-Song Yan#, Christophe Leboeuf, Yan-Yan Liu, Wei-Li Wu, Anne Janinc, Zhu Chen, Sai-Juan Chen*. Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin’s B-lymphoma cells apoptosis. Experimental Hematology 2007;35(12):1801-1811.
  44. Guang-Biao Zhou#, Hui Kang#, Lan Wang#, Li Gao, Ping Liu, Jun Xie, Feng-Xiang Zhang, Xiang-Qin Weng, Zhi-Xiang Shen, Jue Chen, Long-Jun Gu, Ming Yan, Dong-Er Zhang, Sai-Juan Chen, Zhen-Yi Wang, Zhu Chen*. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. Blood 2007;109(8):3441-3450.
  45. Lan Wang, W-L Zhao, J-S Yan, P Liu, H-P Sun, G-B Zhou, Z-Y Weng, W-L Wu, X-Q Weng, X-J Sun, Z Chen*, H-D Sun*, S-J Chen*. Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death and Differentiation 2007;14(2):306-317.
  46. Lan Wang, Sai-Juan Chen. Monoclonal antibodies treat hematopoietic malignancies. Shanghai: Shanghai Science and Technology Press 2006;pp.309-322.
  47. Xiao-Jian Sun, Ju Wei, Xin-Yan Wu, Ming Hu, Lan Wang, Hai-Hong Wang, Qing-Hua Zhang, Sai-Juan Chen, Qiu-Hua Huang*, Zhu Chen*. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem 2005;280(42):35261-35271.
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