郵箱: yinghao@sinh.ac.cn
電話: +86-21-54920247
所屬部門: 中國科學(xué)院營養(yǎng)代謝與食品安全重點實驗室
2017-至 今：中國科學(xué)院上海營養(yǎng)與健康研究所 研究員
2008-2016年：中國科學(xué)院上海生命科學(xué)研究院營養(yǎng)科學(xué)研究所 研究員
2006-2008年：美國國家健康研究院國立癌癥研究所 Staff Scientist
2001-2006年：美國國家健康研究院國立癌癥研究所 博士后
1996-2001年：中國科學(xué)院上海生命科學(xué)研究院生化與細胞所 博士
1992-1996年：華東理工大學(xué)生物工程系 學(xué)士
內(nèi)分泌代謝
1. 甲狀腺激素及受其調(diào)控的非編碼RNA在代謝調(diào)控中的作用
利用甲亢甲減及甲狀腺激素受體敲除小鼠研究甲狀腺激素調(diào)控網(wǎng)絡(luò)中的非編碼RNA，試圖揭示這些非編碼RNA是如何介導(dǎo)甲狀腺激素對代謝的調(diào)控作用的。課題組近期篩選并研究了多個受甲狀腺激素調(diào)控的微小RNA，揭示了這些miRNA對肝臟胰島素信號通路、骨骼肌肌纖維分型和能源物質(zhì)利用的調(diào)控作用及相關(guān)病理生理機制，發(fā)現(xiàn)多個潛在的藥物干預(yù)靶點。
2. 甲狀腺激素的非基因組作用在代謝調(diào)控中的作用
以受甲狀腺激素調(diào)控的p38信號通路為突破口，研究甲狀腺激素通過非基因組作用調(diào)控代謝的分子機制。課題組近期揭示p38可通過AMPK調(diào)控肝臟糖異生，發(fā)現(xiàn)抑制p38信號通路對白色脂肪米色化有促進作用，探索了多個潛在藥物靶點治療相關(guān)代謝性疾病的可行性。
3. 甲狀腺腫瘤
建立甲狀腺腫瘤小鼠模型，研究甲狀腺腫瘤發(fā)生和發(fā)展的分子機制，發(fā)現(xiàn)甲狀腺腫瘤的診斷標志物和潛在的藥物靶點。
1.?Ma Y#, Shen S#, Yan Y, Zhang S, Liu S, Tang Z, Yu J, Ma M, Niu Z, Li Z, Wu Y, Zhao L, Lu Z, Wei C, Zhang WJ, Xue Y, Zhai Q, Li Y, Hu C, Jiang J*, Li Y*, Ying H*. Adipocyte Thyroid Hormone β Receptor-Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis. Diabetes 2023 May 1;72(5):562-574.
2.?Yu J, Shen S, Yan Y, Liu L, Luo R, Liu S, Wu Y, Li Y, Jiang J, Ying H*. Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation. Nutrients 2023 Feb 9;15(4):887.
3.?Tang Z, Sun C, Yan Y, Niu Z, Li Y, Xu X, Zhang J, Wu Y, Li Y, Wang L, Hu C, Li Z*, Jiang J*, Ying H*. Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs. J Mol Cell Biol 2023 Feb 7;14(9):mjac061.
4.?Yan Y, Niu Z, Sun C, Li P, Shen S, Liu S, Wu Y, Yun C, Jiao T, Jia S, Li Y, Fang ZZ, Zhao L, Wang J, Xie C, Jiang C, Li Y, Feng X, Hu C, Jiang J*, Ying H*. Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism. Nat Commun 2022 Oct 27;13(1):6408.
5.?Liu S#, Shen S#, Yan Y, Sun C, Lu Z, Feng H, Ma Y, Tang Z, Yu J, Wu Y, Gereben B, Mohácsik P, Fekete C, Feng X, Yuan F, Guo F, Hu C, Shao M, Gao X, Zhao L, Li Y, Jiang J*, Ying H*. Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation. Nat Commun 2022 Jun 13;13(1):3394.
6.?Liu W, Sun C, Yan Y, Cao H, Niu Z, Shen S, Liu S, Wu Y, Li Y, Hui L, Li Y, Zhao L, Hu C, Ding Q, Jiang J*, Ying H*. Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication. Diabetes 2021 Oct 21:db210240.
7.?Sun C, Liu W, Lu Z, Li Y, Liu S, Tang Z, Yan Y, Li Z, Feng H, Zhang D, Liu Y, Fang ZZ, Jiang C, Ding Q, Jiang J*, Ying H*. Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis. Theranostics 2021 Feb 25;11(9):4363-4380.
8.?Yuan F, Yin H, Deng Y, Jiao F, Jiang H, Niu Y, Chen S, Ying H, Zhai Q, Chen Y, Guo F. Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling. Mol Metab 2020 Dec;42:101084.
9.?Wei Y, Tian C, Zhao Y, Liu X, Liu F, Li S, Chen Y, Qiu Y, Feng Z, Chen L, Zhou T, Ren X, Feng C, Liu Y, Yu W, Ying H, Ding Q. MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism. Nat Metab 2020 May;2(5):447-460.
10.?Cheng Y, Liu J, Luan Y, Liu Z, Lai H, Zhong W, Yang Y, Yu H, Feng N, Wang H, Huang R, He Z, Yan M, Zhang F, Sun YG, Ying H, Guo F, Zhai Q. Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice. Diabetes 2019 Nov;68(11):2120-2130.
11.?Li Y, Pan H, Zhang X, Wang H, Liu S, Zhang H, Qian H, Wang L, Ying H*. Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle. J Agric Food Chem 2019 Apr 24;67(16):4483-4492.
12.?Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Cell Rep 2019 Jan 22;26(4):884-892.e4.
13.?Li Y, Jiang J, Liu W, Wang H, Zhao L, Liu S, Li P, Zhang S, Sun C, Wu Y, Yu S, Li X, Zhang H, Qian H, Zhang D, Guo F, Zhai Q, Ding Q, Wang L, Ying H*. microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10849-E10858.
14.?Li Y, Fan Y, Pan H, Qian H, Qi X, Wu G, Zhang H, Xu M, Rao Z, Wang L, Ying H*. Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells. Int J Biol Macromol 2018 Oct 1;117:287-293.
15.?Sun Y, Wang H, Li Y, Liu S, Chen J, Ying H*. miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-β/Smad Signaling Pathway in Skeletal Muscle Fibrosis. Mol Ther Nucleic Acids 2018 Jun 1;11:528-537.
16.?Zhang S, Cao H, Li Y, Jing Y, Liu S, Ye C, Wang H, Yu S, Peng C, Hui L, Wang YC, Zhang H, Guo F, Zhai Q, Wang H, Huang R, Zhang L, Jiang J, Liu W, Ying H*. Metabolic benefits of inhibition of p38α in white adipose tissue in obesity. PLoS Biol 2018 May 11;16(5):e2004225.
17.?Liu J, Zhang S, Cao H, Wang H, Sun C, Liu S, Yu S, Li Y, Liu W, Wang H, Jiang J, Ying H*. Deficiency of p38α in macrophage ameliorates d-galactosamine/TNF-α-induced acute liver injury in mice. FEBS J 2017 Dec;284(24):4200-4215
18.?Cao H, Zhang S, Shan S, Sun C, Li Y, Wang H, Yu S, Liu Y, Guo F, Zhai Q, Wang YC, Jiang J, Wang H, Yan J, Liu W*, Ying H*. Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation. J Biol Chem 2017 Nov 17;292(46):18973-18987.
19.?Zhang D, Li Y, Liu S, Wang YC, Guo F, Zhai Q, Jiang J, Ying H*. microRNA and thyroid hormone signaling in cardiac and skeletal muscle. Cell Biosci 2017 Mar 21;7:14.
20.?Zhang D, Li Y, Yao X, Wang H, Zhao L, Jiang H, Yao X, Zhang S, Ye C, Liu W, Cao H, Yu S, Wang YC, Li Q, Jiang J, Liu Y, Zhang L, Liu Y, Iwai N, Wang H, Li J, Li J, Li X, Jin ZB*, Ying H*. miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle. Cell Rep 2016 Jul 19;16(3):757-768.
21.?Li Y, Zhang D, Wang X, Yao X, Ye C, Zhang S, Wang H, Chang C, Xia H, Wang YC, Fang J, Yan J, Ying H*. Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer. Sci Rep 2015 Jul 24;5:12495.
22.?Liu W, Cao H, Yan J, Huang R, Ying H*. 'Micro-managers' of hepatic lipid metabolism and NAFLD. Wiley Interdiscip Rev RNA 2015 Sep-Oct;6(5):581-593.
23.?Yao X, Sa R, Ye C, Zhang D, Zhang S, Xia H, Wang YC, Jiang J, Yin H*, Ying H*. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. Prostaglandins Other Lipid Mediat 2015 Apr-Jun;118-119:11-18
24.?Jing Y, Liu W, Cao H, Zhang D, Yao X, Zhang S, Xia H, Li D, Wang YC, Yan J, Hui L, Ying H*. Hepatic p38α regulates gluconeogenesis by suppressing AMPK. J Hepatol 2015 Jun;62(6):1319-1327.
25.?Zhang D, Wang X, Li Y, Zhao L, Lu M, Yao X, Xia H, Wang YC, Liu MF, Jiang J, Li X, Ying H*. Thyroid hormone regulates muscle fiber type conversion via miR-133a1. J Cell Biol 2014 Dec 22;207(6):753-766.
26.?Liu W, Cao H, Ye C, Chang C, Lu M, Jing Y, Zhang D, Yao X, Duan Z, Xia H, Wang YC, Jiang J, Liu MF, Yan J, Ying H*. Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling. Nat Commun 2014 Dec 4;5:5684.
27.?Yao X, Hou S, Zhang D, Xia H, Wang YC, Jiang J, Yin H, Ying H*. Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. Cell Biosci 2014 Jul 30;4:38.
28.?Li X*, Li Y, Zhao L, Zhang D, Yao X, Zhang H, Wang YC, Wang XY, Xia H, Yan J, Ying H*. Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients. Mol Ther Nucleic Acids 2014 Jul 22;3(7):e177.
29.?Chen Z, Liu J, Fu Z, Ye C, Zhang R, Song Y, Zhang Y, Li H, Ying H*, Liu H*. 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist. J Agric Food Chem 2014 Jul 2;62(26):6130-6137.
30.?Yao X, Xia H, Wang YC, Ying H*. Thyroid Hormone Receptor Coregulators in Metabolic Regulation. J Endocrinol Diabetes Obes 2014 Jul 19;2(3):1051.
31.?Wang YC, Li Y*, Wang XY, Zhang D, Zhang H, Wu Q, He YQ, Wang JY, Zhang L, Xia H, Yan J, Li X, Ying H*. Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity. Diabetologia 2013 Oct;56(10):2275-2285.
32.?Zhang D, Li X, Chen C, Li Y, Zhao L, Jing Y, Liu W, Wang X, Zhang Y, Xia H, Chang Y, Gao X, Yan J, Ying H*. Attenuation of p38-mediated miR-1/133 expression facilitates myoblast proliferation during the early stage of muscle regeneration. PLoS One 2012 Jul 24;7(7):e41478.
33.?Song Y, Shan S, Zhang Y, Liu W, Ding W, Ren W, Xia H, Li X, Zhang Q, Zhao L, Li X, Yan J, Ying H*. Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice. J Hepatol 2012 Jan;56(1):248-254.
34.?Yao X, Shan S, Zhang Y, Ying H*. Recent progress in the study of brown adipose tissue. Cell Biosci 2011 Oct 28;1:35.
35.?Song Y, Yao X, Ying H*. Thyroid hormone action in metabolic regulation. Protein Cell 2011 May;2(5):358-368.
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