郵箱: lxzhan@sinh.ac.cn
電話: +86-21-54920978
所屬部門: 中國科學(xué)院營養(yǎng)代謝與食品安全重點(diǎn)實(shí)驗(yàn)室
2017-至 今：中國科學(xué)院上海營養(yǎng)與健康研究所 研究員
2010-2016年：中國科學(xué)院上海生命科學(xué)研究院營養(yǎng)科學(xué)研究所?研究員
2004-2010年：美國冷泉港實(shí)驗(yàn)室 博士后
1998-2003年：中國人民解放軍第二軍醫(yī)大學(xué) 內(nèi)科學(xué)專業(yè) 博士
1991-1996年：浙江醫(yī)科大學(xué) 臨床醫(yī)學(xué)專業(yè) 學(xué)士
腫瘤代謝及細(xì)胞極性的分子調(diào)控機(jī)制
1. 深入探討上皮細(xì)胞中的極性基因功能以及在上皮屏障中的重要分子機(jī)制，上皮細(xì)胞命運(yùn)調(diào)控過程中極性信號的關(guān)鍵機(jī)制，比如在自噬以及壞死性凋亡(necroptosis)中的調(diào)控機(jī)制，并探討上皮細(xì)胞屏障破壞和和修復(fù)過程中極性基因的調(diào)控機(jī)制，以及上皮細(xì)胞屏障破壞與腫瘤發(fā)生的作用機(jī)制研究。
2. 以腫瘤原位移植技術(shù)結(jié)合生物信息學(xué)，分子生物學(xué)方法，獲得腫瘤在肺部轉(zhuǎn)移和定值中的關(guān)鍵分子節(jié)點(diǎn)，上皮細(xì)胞EMT和MET轉(zhuǎn)化過程中極性信號的調(diào)控機(jī)制，以及在遠(yuǎn)端轉(zhuǎn)移中的相關(guān)機(jī)制。
3. 以目前先進(jìn)的類器官技術(shù)（organoid），進(jìn)一步探討上皮細(xì)胞穩(wěn)態(tài)(Homeostasis)打破與損傷修復(fù)中極性通路的新功能，來研究腫瘤早期發(fā)生中與腫瘤微環(huán)境的相互作用，從而明確極性信號在決定上皮細(xì)胞命運(yùn)以及異質(zhì)性中的分子機(jī)制。
1.?Qi M, Xia Y, Wu Y, Zhang Z, Wang X, Lu L, Dai C, Song Y, Xu K, Ji W, Zhan L*. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun 2022 Feb 16;13(1):897
2.?Song L#, Chang R#, Sun X, Lu L, Gao H, Lu H, Lin R, Xu X, Liu Z*, Zhan L*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Commun Biol 2021 Feb 16;4(1):213
3.?Guo C, Peng X, Song L, Ying M, Wu Y, Chang R, Li J, Feng D*, Zhan L*, Zhan X. Autophagy promotes malignant migration and invasion via miR-224-5p/BCL2 in pancreatic mucinous cystadenocarcinoma MCC1 cells. Oncol Lett 2020 Dec;20(6):276
4.?Wang N#, Song L#, Xu Y#, Zhang L, Wu Y, Guo J, Ji W, Li L, Zhao J, Zhang X*, Zhan L*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EBioMedicine 2019 Sep;47:65-77
5.?Dai C, Wang X, Wu Y, Xu Y, Zhuo S, Qi M, Ji W, Zhan L*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner. Diabetes 2019 Aug;68(8):1577-1590
6.?Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, Zhan L*. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nat Commun 2018 Aug 28;9(1):3486
7.?Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang*, Lixing Zhan*, Haiyun Song*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles. ACS Appl Mater Interfaces 2018 Jan 31;10(4):3449-3458
8.?Zheng Chao, Wang Yuetong, Yang Liu, Zhou Shuhua, Gao Yijun, Li Fuming, Feng Yan, Wang Zuoyun, Zhan Lixing, Yan Qin, Zhu Xueliang, Wong Kwok-Kin, Chen Zhengjun, Ji Hongbin*. Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis. Sci Rep 2017 Sep 4;7(1):10407
9.?Song Lele, Chang Renxu, Dai Cheng, Wu Yanjun, Guo Jingyu, Qi Meiyan, Zhou Wu*, Zhan Lixing*. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancerto chemotherapy drug. Oncotarget 2017 Feb 7;8(6):9108-9122
10.?Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, Lin X, Feng XH*. STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling. Oncogene 2016 Aug 18;35(33):4388-4398
11.?Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, Zhan L, Xu P, Ehrlich M, Liang T, Lin X, Feng XH*. Loss of α-Tubulin Acetylation isAssociated with TGF-β-induced EpithelialMesenchymal Transition. J Biol Chem 2016 Mar 4;291(10):5396-5405
12.?Zhou Y, Chang R, Ji W, Wang N, Qi M, Xu Y, Guo J, Zhan L*. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. J Biol Chem 2016 Jan 1;291(1):291-302
13.?Xu Yi, Chang Renxu, Peng Zhiyong, Wang Yanmei, Ji Weiwei, Guo Jingyu, Song Lele, Dai Cheng, Wei Wei, Wu Yanjun, Wan Xinjian, Shao Chenghao, Zhan Lixing*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nat Commun 2015 May 26;6:7184
14.?Guo J, Xu Y, Ji W, Song L, Dai C, Zhan L*. Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicol Lett 2015 May 5;234(3):201-210
15.?Guo Jingyu, Wei Wei, Zhan Lixing*. Red and processed meat intake and risk of breast cancer:a meta-analysis of prospective studies. Breast Cancer Res Treat 2015 May;151(1):191-198
16.?Fatao Liu, Yi Zhou, Daizhan Zhou, Mengyuan Kan, Xiaomin Niu, Zhou Zhang, Di Zhang, Liming Tao, Lin He, Lixing Zhan*, Yun Liu*. Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition. Diagn Pathol 2014 Mar 20;9:66
17.?Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR*. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 2012 Jan 15;19(2):220-228
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