Title: Wired to be human: Insights from transcriptome analysis
Speaker: Prof. Ying ZHU 諸穎
Institutes of Brain Science, Fudan University
Time: 14:00-17:00 PM, April 8(Monday)
Venue: Room 300, 320 Yueyang Road
Host: Prof. Guang-Zhong Wang
CAS-MPG Partner Institute for Computational Biology
Abstract: Although the human brain is about three times as large as those of our closest living relatives, the nonhuman African great apes, increased size and neural cell counts alone fail to explain its characteristic functionalities. The brain has also undergone microstructural, connectional, and molecular changes in the human lineage, changes likely me-diated by divergent spatiotemporal gene expression. Our integrative analysis of tissue and single-cell transcriptomic data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.
諸穎，研究員，復(fù)旦大學(xué)腦科學(xué)研究院
2008畢業(yè)于清華大學(xué)獲得生物學(xué)學(xué)士學(xué)位，2014年畢業(yè)于美國(guó)耶魯大學(xué)獲得神經(jīng)生物學(xué)博士學(xué)位。2014至2017年，于美國(guó)耶魯大學(xué)生物統(tǒng)計(jì)系和神經(jīng)生物學(xué)系進(jìn)行聯(lián)合博士后研究工作，2017年至2019年初于美國(guó)耶魯大學(xué)擔(dān)任副研究科學(xué)家。于2019年加入復(fù)旦大學(xué)腦科學(xué)研究院。其研究成果發(fā)表在 Nature, Science等多家知名期刊上。
研究方向
大腦發(fā)育涉及復(fù)雜的過程，需要在時(shí)序上精確的基因調(diào)控。本實(shí)驗(yàn)室運(yùn)用生物信息學(xué)的方法，通過整合分析‘omics’數(shù)據(jù)，研究人腦在發(fā)育、進(jìn)化，以及相關(guān)疾病中的分子和細(xì)胞機(jī)制。
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