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全體研究組長
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馮英

馮英

博士
代謝性疾病研究研究組組長

郵箱: fengying@sinh.ac.cn

電話: +86-21-54920965

所屬部門: 中國科學(xué)院營養(yǎng)代謝與食品安全重點(diǎn)實(shí)驗(yàn)室

個(gè)人簡歷

2017-至???今：中國科學(xué)院上海營養(yǎng)與健康研究所 研究員
2008-2016年：中國科學(xué)院上海生命科學(xué)研究院營養(yǎng)科學(xué)研究所 研究員
2008-2006年：哥倫比亞大學(xué)，Research Associate Scientist
2001-2006年：哥倫比亞大學(xué)博士后
1998-2001年：中國科學(xué)院上海生命科學(xué)研究院生化與細(xì)胞研究所 生物化學(xué)與分子生物學(xué)博士
1995-1998年：衛(wèi)生部北京生物制品研究所 醫(yī)學(xué)免疫學(xué)碩士
　　

研究方向

可變剪接調(diào)控在代謝性疾病的調(diào)控研究

研究內(nèi)容

長期致力于mRNA前體可變剪接精細(xì)調(diào)控的研究。利用敲除動(dòng)物模型和細(xì)胞模型，結(jié)合高通量測(cè)序和生物信息學(xué)分析，深入研究可變剪接的精細(xì)調(diào)控機(jī)制以及剪接調(diào)控失常在發(fā)育或疾病包括腫瘤中的作用機(jī)理。
　　

代表論著（#第一作者，*通訊作者）

  1. Guo R, You X, Meng K, Sha R, Wang Z, Yuan N, Peng Q, Li Z, Xie Z, Chen R*, Feng Y*. Single-cell RNA sequencing reveals heterogeneity of Myf5-derived cells and altered myogenic fate in the absence of SRSF2. Adv Sci 2022 Jun;9(18):e2105775
  2. Zheng Zhan#, Ningyang Yuan#, Xue You, Kai Meng, Rula Sha, Zhenzhen Wang, Qian Peng, Zhiqin Xie, Ruijiao Chen*, Ying Feng*. Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk. Int J Mol Sci 2022 Apr 14;23(8):4363
  3. Sha R#, Wang Z#, You X, Liu Y, Xie Z, Feng Y*. Whole-mount Staining of Mouse Diaphragm Neuromuscular Junctions. Bio Protoc 2021 Nov 5;11(21):e4215
  4. Liu Y, Luo Y, Shen L, Guo R, Zhan Z, Yuan N, Sha R, Qian W, Wang Z, Xie Z, Wu W*, Feng Y*. Splicing factor SRSF1 is essential for satellite cell proliferation and postnatal maturation of neuromuscular junctions in mice. Stem Cell Reports 2020 Oct 13;15(4):941-954
  5. Zhang C, Shen L, Yuan W, Liu Y, Guo R, Luo Y, Zhan Z, Xie Z, Wu G, Wu W*, Feng Y*. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mic. Commun Biol 2020 May 5;3(1):210
  6. Wang Q, Wang Y, Liu Y, Zhang C, Luo Y, Guo R, Zhan Z, Wei N, Xie Z, Shen L,?Wu G, Wu W, Feng Y*. U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation. Int J Cancer 2019 Nov 15;145(10):2728-2739
  7. Shen L, Han J, Wang H, Meng Q, Chen L, Liu Y, Feng Y* (co-corresponding), Wu G*. Cachexia-related long noncoding RNA, CAAlnc1, suppresses adipogenesis by blocking the binding of HuR to adipogenic transcription factor mRNAs. Int J Cancer 2019 Oct 1;145(7):1809-1821
  8. Wu W*, Zong J, Wei N, Cheng J, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B, Feng Y*. CASH: a constructing comprehensive splice site method for detecting alternative splicing events. Brief Bioinform 2018 Sep 28;19(5):905-917
  9. Liu L, Luo C, Luo Y, Chen L, Liu Y, Zhang Y, Xie Z, Wu W, Wu G*, Feng Y*. MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression. Oncogene 2018 Jan 4;37(1):86-94
  10. Chen L, Luo C, Liu Y, Wang Q, Guo R, Zhang Y, Xie Z, Wei N, Wu W, Han J*, Feng Y*. SRSF1 prevents DNA damage and promotes tumorigenesis through regulating DBF4B pre-mRNA splicing. Cell Rep 2017 Dec 19;21(12):3406-3413
  11. Wei N, Feng X, Xie Z, Zhang Y, Feng Y*. Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFκB. Toxicol In Vitro 2017 Apr 13;42:86-92
  12. Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z, Wu W, Feng Y*. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Cancer Res 2017 Mar 1;77(5):1168-1178
  13. Cheng Y, Luo C, Wu W, Xie Z, Fu X, Feng Y*. Liver-Specific Deletion of SC35/SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol Cell Biol 2016 May 16;36(11):1628-1638
  14. Wei N, Cheng Y, Wang Z, Liu Y, Luo C, Liu L, Chen L, Xie A, Lu Y, Feng Y*. ASF/SRSF10 plays a role in myoblast differentiation and glucose production via regulation of alternative splicing. Cell Rep 2015 Nov 24;13(8):1647-1657
  15. Zhou X，Li X，Cheng Y, Wu W, Xie Z, Xi Q, Han J, Wu G, Fang J, Feng Y*. BCLAF1 and its splicing regulator SRSF10 regulate tumorigenic potential of colon cancer cells. Nat Commun 2014 Aug 5;5:4581
  16. Li H, Cheng Y, Wu W, Liu Y, Wei N, Feng X, Xie Z, Feng Y*. SRSF10 regulates alternative splicing and is required for adipocyte differentiation. Mol Cell Biol 2014 Jun 15;34(12):2198-2207
  17. Zhou X, Wu W, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H, Feng Y*. Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res 2014 Apr;42(6):4019-4030
  18. Zhou X, Wu W, Wei N, Cheng Y, Xie Z, Feng Y*. Genome-wide analysis of SRSF10-regulated alternative splicing by deep sequencing of chicken transcriptome. Genomics Data 2014 Mar 12;2:20-23
  19. Li H, Wang Z, Zhou X, Cheng Y, Xie Z, Manley JL, Feng Y*. Binding of FUBP1 to an exonic splicing silencer and RNA secondary structure mediate second-step splicing repression. Proc Natl Acad Sci U S A 2013 Jul 16;110(29):E2687-E2695
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