郵箱: yyle@sinh.ac.cn
電話(huà): +86-21-54920901
所屬部門(mén): 中國(guó)科學(xué)院營(yíng)養(yǎng)代謝與食品安全重點(diǎn)實(shí)驗(yàn)室
2017-至???今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 研究員
2004-2016年：中國(guó)科學(xué)院上海生命科學(xué)研究院營(yíng)養(yǎng)科學(xué)研究所 研究員
1999-2004年：美國(guó)國(guó)立衛(wèi)生研究院 (NIH), Frederick-NCI 博士后
1992-1998年：第一軍醫(yī)大學(xué)基礎(chǔ)部生理學(xué)教研室 講師，副教授，副主任
1989-1992年：第二軍醫(yī)大學(xué)生理學(xué)專(zhuān)業(yè) 博士
1986-1989年：第二軍醫(yī)大學(xué)病理生理學(xué)專(zhuān)業(yè) 碩士
糖脂代謝穩(wěn)態(tài)調(diào)控及紊亂相關(guān)疾病
1.通過(guò)分子和細(xì)胞生物學(xué)、生物化學(xué)手段，在細(xì)胞和動(dòng)物水平研究糖脂代謝穩(wěn)態(tài)調(diào)控機(jī)制，探討營(yíng)養(yǎng)失衡、慢性炎癥等在肥胖、糖尿病和脂肪肝等代謝性疾病以及神經(jīng)退行性疾病中的作用及機(jī)制，尋找能干預(yù)這些疾病的靶標(biāo)和化合物。
2.食品相關(guān)有毒有害物質(zhì)的檢測(cè)技術(shù)及毒性機(jī)理研究。
1.?Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang JM, Chen S, Ye RD, Li Y, Le Y*. Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization. Diabetes 2019 Jun;68(6):1130-1142.
2.?Li N, Wang T, Li Z, Ye X, Deng B, Zhuo S, Yao P, Yang M, Mei H, Chen X, Zhu T, Chen S, Wang H, Wang J, Le Y*. Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels. Cancer Biol Med 2019 May;16(2):220-233.
3.?Wan D, Fu Y, Le Y*, Zhang P, Ju J, Wang B, Zhang G, Wang Z, Su H, Wang L, Hou R*. Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating β-Catenin, c-Myc, and Cyclin Expression. Stem Cells Int 2019 Jun 2;2019:1575480.
4.?Chen K, Tang P, Bao Z, He T, Xiang Y, Gong W, Yoshimura T, Le Y, Tessarollo L, Chen X, Wang JM. Deficiency in Fpr2 results in reduced numbers of Lin(-)cKit(+)Sca1(+) myeloid progenitor cells. J Biol Chem 2018;293(35):13452-13463.
5.?Yu Y, Bao Z, Wang X, Gong W, Chen H, Guan H, Le Y, Su S, Chen K, Wang JM. The G-Protein-Coupled Chemoattractant Receptor Fpr2 Exacerbates High Glucose-Mediated Proinflammatory Responses of Müller Glial Cells. Front Immunol 2017;8:1852.
6.?Yao PL, Zhuo S, Mei H, Chen XF, Li N, Zhu TF, Chen ST, Wang JM, Hou RX, Le YY*. Androgen alleviates neurotoxicity of β-amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ. CNS Neurosci Ther 2017;23(11):855-865.
7.?Mei H, Yao P, Wang S, Li N, Zhu T, Chen X, Yang M, Zhuo S, Chen S, Wang JM, Wang H, Xie D, Wu Y, Le Y*. Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury. Toxicol Sci 2017;159(2):327-338.
8.?Zhuo S, Yang M, Zhao Y, Chen X, Zhang F, Li N, Yao P, Zhu T, Mei H, Wang S, Li Y, Chen S, Le Y*. MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase-Mediated Gluconeogenesis. Diabetes 2016;65(11):3276-3288.
9.?Zhang L, Wang H, Yang T, Su Z, Fang D, Wang Y, Fang J, Hou X, Le Y, Chen K, Wang JM, Su SB, Lin Q, Zhou Q. Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells. Oncoimmunology 2015;5(2):e1078055.
10.?Chen K, Xiang Y, Huang J, Gong W, Yoshimura T, Jiang Q, Tessarollo L, Le Y, Wang JM. The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation. J Biol Chem 2014;289(25):17553-17563.
11.?Chen F, Qian LH, Deng B, Liu ZM, Zhao Y, Le YY*. Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress. CNS Neurosci Ther 2013;19(9):675-681.
12.?Zhang Y, Zhou B, Deng B, Zhang F, Wu J, Wang Y, Le Y*, Zhai Q*. Amyloid-β induces hepatic insulin resistance in vivo via JAK2. Diabetes 2013;62(4):1159-1166.
13.?Mou H, Li Z, Yao P, Zhuo S, Luan W, Deng B, Qian L, Yang M, Mei H, Le Y*. Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. Int J Biochem Cell Biol 2013;45(3):684-691.
14.?Chen K, Liu M, Liu Y, Yoshimura T, Shen W, Le Y, Durum S, Gong W, Wang C, Gao JL, Murphy PM, Wang JM. Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis. J Clin Invest 2013;123(4):1694-1704.
15.?Li Z, Mou H, Wang T, Xue J, Deng B, Qian L, Zhou Y, Gong W, Wang JM, Wu G, Zhou CF, Fang J, Le Y*. A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression. Cancer Lett 2013;328(2):278-284.
16.?Zhang L, Pang S, Deng B, Qian L, Chen J, Zou J, Zheng J, Yang L, Zhang C, Chen X, Liu Z, Le Y*. High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. Int J Biochem Cell Biol 2012;44(4):629-638.
17.?Hou X, Wang O, Li Z, Mou H, Chen J, Deng B, Qian L, Liu X, Le Y*. Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2). Mol Cell Endocrinol 2011;343(1-2):18-24.
18.?Cai K, Qi D, Wang O, Chen J, Liu X, Deng B, Qian L, Liu X, Le Y*. TNF-α acutely upregulates amylin expression in murine pancreatic beta cells. Diabetologia 2011;54(3):617-626.
19.?Pang S, Tang H, Zhuo S, Zang YQ, Le Y*. Regulation of fasting fuel metabolism by toll-like receptor 4. Diabetes 2010;59(12):3041-3048.
20.?Kong Y, Ruan L, Qian L, Liu X, Le Y*. Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme. J Neurosci 2010;30(35):11848-11857.
21.?Qi D, Cai K, Wang O, Li Z, Chen J, Deng B, Qian L, Le Y*. Fatty acids induce amylin expression and secretion by pancreatic beta-cells. Am J Physiol Endocrinol Metab 2010;298(1):E99-E107.
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