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全體研究組長
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秦駿

秦駿

博士
腫瘤細胞可塑性研究組組長

郵箱: qinjun@sinh.ac.cn

電話: +86-21-54923326

所屬部門: 中國科學(xué)院腫瘤與微環(huán)境重點實驗室

個人簡歷

2017-至　 今：中國科學(xué)院上海營養(yǎng)與健康研究所，研究員
2014-2016年：中國科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所 研究員
2012-2014年：美國貝勒醫(yī)學(xué)院 助理教授
2005-2012年：美國貝勒醫(yī)學(xué)院 博士后
2000-2005年：中國科學(xué)院上海生命科學(xué)研究院生化與細胞所 博士

研究方向

腫瘤細胞可塑性的表觀遺傳調(diào)控

研究內(nèi)容

可塑性調(diào)控在藥物抵抗和腫瘤轉(zhuǎn)移中發(fā)揮著至關(guān)重要的作用，同時也是導(dǎo)致腫瘤異質(zhì)性的主要原因之一?？伤苄哉{(diào)控可被理解為細胞改變其身份的過程，包括同一譜系下細胞的分化，或者是細胞譜系的轉(zhuǎn)分化或去分化（例如，針對肺癌和前列腺癌的靶向治療導(dǎo)致下腺癌表型的轉(zhuǎn)變?yōu)樯窠?jīng)內(nèi)分泌腫瘤，以及干細胞的惡性轉(zhuǎn)化、腫瘤EMT和MET在腫瘤轉(zhuǎn)移過程中的動態(tài)變化等）。進一步可塑性調(diào)控也可擴展至腫瘤整體表型的轉(zhuǎn)變，例如惰性腫瘤的進展演化以及轉(zhuǎn)移過程中腫瘤的休眠和蘇醒等現(xiàn)象。
我們的研究以表觀遺傳調(diào)控與腫瘤細胞命運決定及微環(huán)境重塑為核心，聚焦前列腺癌及腸癌診治中的臨床重大需求，探究表觀遺傳調(diào)控在腫瘤轉(zhuǎn)移及耐藥中的功能，并基于此提出潛在的治療策略；闡明表觀遺傳相關(guān)基因如何響應(yīng)藥物治療、代謝、炎癥等信號調(diào)控組蛋白修飾及染色質(zhì)重塑進而決定腫瘤及微環(huán)境細胞的命運及功能。

代表論著（#第一作者，*通訊作者）

  1. Guo J#, Li N#,*, Liu Q#, Hao Z, Zhu G, Wang X, Wang H, Pan Q, Xu B, Han Y, Zhang G, Lian Y, Zhang W, Gu Y, Lin N, Zeng X, Jin Z, Lan W, Jiang J, Gao D, Dong L*, Yuan H*, Liang C*, Qin J*. KMT2C Deficiency Drives the Transdifferentiation of Double-Negative Prostate Cancer and Confer Resistance to AR-Targeted Therapy. Cancer Cell 2025;43(7):1261-1278
  2. Zhu Q#, Zhang G#, Cao M#, Huang H#, He D, Xing J, Zhan M, Pei S, Deng X, Xu J, Zheng M, Liu C*, Qin J*, Xiao Y*. Microbiota-shaped neutrophil senescence imparts the sexual difference in bladder cancer. Nature Immunology 2025;26(5):722-736
  3. Zhang G#, Lian Y#, Li Q#, Zhou S#, Zhang L, Chen L, Tang J, Liu H, Li N, Pan Q, Gu Y, Lin Nai, Wang H, Wang X, Guo J, Zhang W, Jin Z, Xu B, Su X*, Lin M*, Han Q*, Qin J*. Vagal pathway activation links chronic stress to decline in intestinal stem cell function. Cell Stem Cell 2025;32(5):778-794
  4. Wang H#, Zhang S#, Pan Q#, Guo J, Li N, Chen L, Xu J, Zhou J, Gu Y, Wang X, Zhang G, Lian Y, Zhang W, Lin N, Jin Z, Zang Y, Lan W, Cheng X, Tan M, Chen F, Jiang J, Liu Q*, Zheng M*, Qin J*. Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer. Nature Cancer 2025;6(4):629-646
  5. Teng M#, Guo J#, Xu X#, Ci X, Mo Y, Kohen Y, Ni Z, Chen S, Guo W, Bakht M, Ku S, Sigouros M, Luo W, Macarios CM, Xia Z, Chen M, Haq SU, Yang W, Berlin A, Kwast T, Ellis L, Zoubeidi A, Zheng G, Ming J, Wang Y, Cui H, Lok BH, Raught B, Beltran H*, Qin J*, He H*. Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation. Cancer Cell 2025;43(5):891-904
  6. Dong B#, Xu J# *, Huang Y#, Guo J#, Dong Q#, Wang Y#, Li N, Liu Q, Zhang M, Pan Q, Wang H, Jiang J, Chen B, Shen D, Ma Y, Zhai L, Zhang J, Li J*, Xue W*, Tan M*, Qin J*. Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers. Nature Cancer 2024;5(9):1427-1447
  7. Long X#, Zhang S#, Wang Y#, Chen J#, Lu Y#, Hou H#, Lin B#, Li Q, Shen C, Yang R, Zhu H, Cui R, Cao D, Chen G, Wang D, Chen Y, Zhai S, Zeng Z, Wu S, Lou M, Chen J, Zou J, Zheng M*, Qin J*, Wang X*. Targeting JMJD1C to selectively disrupt tumor Treg fitness enhances anti-tumor immunity. Nature Immunology 2024;25,525–536
  8. Wang H#, Li N#, #, Liu Q#, Guo J, Pan Q, Cheng B, Xu J, Dong B, Yang G, Bin Yang B, Xuege Wang X, Gu Y, Zhang G, Lian Y, Zhang W, Zhang M, Li T, Zang Y, Tan M, Li Q, Wang W, Yu Z, Jiang J*, Huang H*, Qin J*. Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer. Cancer Cell 2023;41,1345–1362
  9. Chen M#, Wang K#, Han Y#, Yan S#, Yuan H, Liu Q, Li L, Li N, Zhu H, Lu D, Wang K, Fen Liu F, Luo D, Zhang Y, Jiang J, Li D, Zhang L, Ji H, Hu Zhou, Chen Y*, Qin J*, Gao D*. Identification of XAF1 as an endogenous AKT inhibitor. Cell Rep 2023;42(7):112690
  10. Peng S#, Wang Z#, Tang P#, Wang S#, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J*, Jiang J*, Liu Q*. PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma. Sci Adv 2023;9(31):eadf3566
  11. Li N#, Liu Q#, Han Y#, Pei S#, Cheng B, Xu J, Miao X, Pan Q, Wang H, Guo J, Wang X, Zhang G, Lian Y, Zhang W, Zang Y, Tan M, Li Q, Wang X, Xiao Y, Hu G, Jiang J*, Huang H*, Qin J*. ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression. Nat Commun 2022;13(1):7281
  12. Ren J#, Li N#, Pei S#, Lian Y, Li L, Peng Y, Liu Q, Guo J, Wang X, Han Y, Zhang G, Wang H, Li Y, Jiang J, Li Q, Tan M, Peng J, Hu G, Xiao Y, Li X*, Lin M*, Qin J*. Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity. J Clin Invest 2022;132(8):e153167
  13. Jia P#, Li X#, Wang X#, Yao L, Xu Y, Hu Y, Xu W, He Z, Zhao Q, Deng Y, Zang Y, Meiyu Zhang M, Zhang Y*, Qin J*, Lu W*. ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization. Nat Commun 2021;12,6535
  14. Pan Q#, Zhong S#, Wang H#, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J*, Xiao Y*, Qin J*. The ZMYND8-regulated Mevalonate Pathway Endows YAP-High Intestinal Cancer with Metabolic Vulnerability. Molecular Cell 2021;81(13):2736-2751
  15. Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 Restrains the Pro-Inflammatory Properties of ILC3s and Modulates Intestinal Immunity. Mucosal Immunol 2021;14(1):38-52
  16. Yuan H#, Han Y#, Wang X#, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X*, Jiang J*, Qin J*. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell 2020 14;38(3):350-365
  17. Yu T#, Gan S#, Zhu Q#, Dai D, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Luo X, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Qin J*, Xiao Y*. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 2019;10(1):4353
  18. Ding Y#, Li N #, Dong B#, Guo W, Wei H, Chen Q, Yuan H, Han Y, Chang H, Kan S, Wang X, Pan Q, Wu P, Peng C, Qiu T, Li Q, Gao D*, Xue W*, Qin J*. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest 2019;129(2):759-773
  19. Chen J, Li N, Yin Y, Zheng N, Min M, Lin B, Zhang L, Long X, Zhang Y, Cai Z, Zhai S, Qin J*, Wang X*. Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells. Cell Rep 2018 18;25(12):3393-3404
  20. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med 2018;215(5):1365-1382
  21. Yuan H#, Li N#, Fu D#, Ren J, Hui J, Peng J, Liu Y, Qiu T, Jiang M, Pan Q, Han Y, Wang X, Li Q, Qin J*. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest 2017;127(9):3375-3391
  22. Liu Y#, Peng J#, Sun T#, Li N, Zhang L, Ren J, Yuan H, Kan S, Pan Q, Li X, Ding Y, Jiang M, Cong X, Tan M, Ma Y, Fu D, Cai S, Xiaog Y, Wang X, Qin J*. Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNF?-mediated inflammation and apoptosis. Proc Natl Acad Sci U S A 2017;114(19):E3796-E3805
  23. Li N#, Xue W#, Yuan H#, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017;127(4):1284-1302
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