郵箱: lxzhan@sinh.ac.cn
電話: +86-21-54920978
所屬部門: 中國科學院營養(yǎng)代謝與食品安全重點實驗室
2017-至 今：中國科學院上海營養(yǎng)與健康研究所 研究員
2010-2016年：中國科學院上海生命科學研究院營養(yǎng)科學研究所?研究員
2004-2010年：美國冷泉港實驗室 博士后
1998-2003年：中國人民解放軍第二軍醫(yī)大學 內科學專業(yè) 博士
1991-1996年：浙江醫(yī)科大學 臨床醫(yī)學專業(yè) 學士
腫瘤代謝及細胞極性的分子調控機制
1. 深入探討上皮細胞中的極性基因功能以及在上皮屏障中的重要分子機制，上皮細胞命運調控過程中極性信號的關鍵機制，比如在自噬以及壞死性凋亡(necroptosis)中的調控機制，并探討上皮細胞屏障破壞和和修復過程中極性基因的調控機制，以及上皮細胞屏障破壞與腫瘤發(fā)生的作用機制研究。
2. 以腫瘤原位移植技術結合生物信息學，分子生物學方法，獲得腫瘤在肺部轉移和定值中的關鍵分子節(jié)點，上皮細胞EMT和MET轉化過程中極性信號的調控機制，以及在遠端轉移中的相關機制。
3. 以目前先進的類器官技術（organoid），進一步探討上皮細胞穩(wěn)態(tài)(Homeostasis)打破與損傷修復中極性通路的新功能，來研究腫瘤早期發(fā)生中與腫瘤微環(huán)境的相互作用，從而明確極性信號在決定上皮細胞命運以及異質性中的分子機制。
1.?Qi M, Xia Y, Wu Y, Zhang Z, Wang X, Lu L, Dai C, Song Y, Xu K, Ji W, Zhan L*. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun 2022 Feb 16;13(1):897
2.?Song L#, Chang R#, Sun X, Lu L, Gao H, Lu H, Lin R, Xu X, Liu Z*, Zhan L*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Commun Biol 2021 Feb 16;4(1):213
3.?Guo C, Peng X, Song L, Ying M, Wu Y, Chang R, Li J, Feng D*, Zhan L*, Zhan X. Autophagy promotes malignant migration and invasion via miR-224-5p/BCL2 in pancreatic mucinous cystadenocarcinoma MCC1 cells. Oncol Lett 2020 Dec;20(6):276
4.?Wang N#, Song L#, Xu Y#, Zhang L, Wu Y, Guo J, Ji W, Li L, Zhao J, Zhang X*, Zhan L*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EBioMedicine 2019 Sep;47:65-77
5.?Dai C, Wang X, Wu Y, Xu Y, Zhuo S, Qi M, Ji W, Zhan L*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner. Diabetes 2019 Aug;68(8):1577-1590
6.?Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, Zhan L*. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nat Commun 2018 Aug 28;9(1):3486
7.?Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang*, Lixing Zhan*, Haiyun Song*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles. ACS Appl Mater Interfaces 2018 Jan 31;10(4):3449-3458
8.?Zheng Chao, Wang Yuetong, Yang Liu, Zhou Shuhua, Gao Yijun, Li Fuming, Feng Yan, Wang Zuoyun, Zhan Lixing, Yan Qin, Zhu Xueliang, Wong Kwok-Kin, Chen Zhengjun, Ji Hongbin*. Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis. Sci Rep 2017 Sep 4;7(1):10407
9.?Song Lele, Chang Renxu, Dai Cheng, Wu Yanjun, Guo Jingyu, Qi Meiyan, Zhou Wu*, Zhan Lixing*. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancerto chemotherapy drug. Oncotarget 2017 Feb 7;8(6):9108-9122
10.?Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, Lin X, Feng XH*. STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling. Oncogene 2016 Aug 18;35(33):4388-4398
11.?Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, Zhan L, Xu P, Ehrlich M, Liang T, Lin X, Feng XH*. Loss of α-Tubulin Acetylation isAssociated with TGF-β-induced EpithelialMesenchymal Transition. J Biol Chem 2016 Mar 4;291(10):5396-5405
12.?Zhou Y, Chang R, Ji W, Wang N, Qi M, Xu Y, Guo J, Zhan L*. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. J Biol Chem 2016 Jan 1;291(1):291-302
13.?Xu Yi, Chang Renxu, Peng Zhiyong, Wang Yanmei, Ji Weiwei, Guo Jingyu, Song Lele, Dai Cheng, Wei Wei, Wu Yanjun, Wan Xinjian, Shao Chenghao, Zhan Lixing*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nat Commun 2015 May 26;6:7184
14.?Guo J, Xu Y, Ji W, Song L, Dai C, Zhan L*. Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicol Lett 2015 May 5;234(3):201-210
15.?Guo Jingyu, Wei Wei, Zhan Lixing*. Red and processed meat intake and risk of breast cancer:a meta-analysis of prospective studies. Breast Cancer Res Treat 2015 May;151(1):191-198
16.?Fatao Liu, Yi Zhou, Daizhan Zhou, Mengyuan Kan, Xiaomin Niu, Zhou Zhang, Di Zhang, Liming Tao, Lin He, Lixing Zhan*, Yun Liu*. Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition. Diagn Pathol 2014 Mar 20;9:66
17.?Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR*. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 2012 Jan 15;19(2):220-228
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