郵箱: zhouyong@sinh.ac.cn
電話: +86-21-54923289
所屬部門: 中國科學(xué)院腫瘤與微環(huán)境重點(diǎn)實(shí)驗(yàn)室
2017-至 今：中國科學(xué)院上海營養(yǎng)與健康研究所，研究員
2011-2016年：中國科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所，研究員
2008-2011年：哈佛醫(yī)學(xué)院，馬薩諸塞總醫(yī)院，心血管研究中心(波士頓，美國)，博士后研究員
2006-2008年：渥太華健康研究所，渥太華大學(xué)(渥太華，加拿大)，博士后研究員
2001-2006年：中國海洋大學(xué)，海洋藥物研究所，教育部海洋藥物重點(diǎn)實(shí)驗(yàn)室(青島)，博士，藥理學(xué)
2002-2006年：中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)科大學(xué)，藥物研究所(北京)，博士聯(lián)合培養(yǎng)，藥理學(xué)
1997-2001年：中國海洋大學(xué)，藥物化學(xué)專業(yè)，醫(yī)學(xué)學(xué)士(青島)
血液與循環(huán)系統(tǒng)疾病研究
1. 心臟的發(fā)生、再生與疾病的微環(huán)境研究：關(guān)注心臟形成的信號調(diào)控與先天性心臟病的致病機(jī)制，以及心肌梗死等的疾病微環(huán)境與再生治療。
2. 血液的形成、分化與疾病的免疫微環(huán)境研究：關(guān)注造血干細(xì)胞形成及向免疫細(xì)胞、紅細(xì)胞分化的信號調(diào)控，以及腫瘤相關(guān)的血液免疫微環(huán)境。
1.?Chu LM, Yin HM, Gao L, Xia Yu, Zhang CY, Chen Y, Liu TX, Huang JJ, Boheler KR, Zhou Y*, Yang HT*. Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Sci China Life Sci 2021 Feb;64(2):255-268
2.?Hui-Min Yin, Li-Feng Yan, Qian Liu, Zheng Peng, Chi-Yuan Zhang, Yu Xia, Dan Su, Ai-Hua Gu*, Yong Zhou*. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science Advances 2020 May 6;6(19):eaay9466
3.?Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-Jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng*, Yong Zhou*, Shuhong Shen*. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica 2020 Apr;105(4):925-936
4.?Zhang Chiyuan, Yin Huimin, Wang He, Su Dan, Xia Yu, Yan Lifeng, Fang Bin, Liu Wei, Wang Yumei, Gu Aihua*, Zhou Yong*. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Leukemia 2018 Feb;32(2):479-491
5.?Meng Zhaozheng, Liu Wei, Xia Yu, Yin Huimin, Zhang Chiyuan, Dan Su, Yan Lifeng, Gu Aihua*, Zhou Yong*. The pro-inflammatorysignalling regulator Stat4 promotes vasculogenesis of great vessels derivedfrom endothelial precursors. Nature Communications 2017 Mar 3;8:14640
6.?X Peng, M Dong, L Ma, X-E Jia, J Mao, C Jin, Y Chen, L Gao, X Liu, K Ma, L Wang, T Du, Y Jin, Q Huang, K Li, LI Zon, T Liu, M Deng*, Y Zhou*, X Xi, Y Zhou*, S Chen*. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia 2015 Jan 1;29:2355-2365
7.?Fan Hongbo, Liu Yijie, Wang Lei, Du Tingting, Gao Li, Meng Zhaozheng, Jin Yi, Chen Yi, Deng Min, Yang Huangtian, Jing Qing, Gu Aihua*, Zhou Yong*. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood 2014 Aug 21;124(8):1320-1330
8.?Dong Zhiwei, Ren Chunguang, Su Dan, Du Tingting, Fan Hongbo, Yuan Hao, Wang Lei, Dong Mei, Li Weichun, Jin Yi, Chen Yi, Deng Min, Liu Tingxi, Gu Aihua*, Zhou Yong*. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology 2014 Mar 5;7(1):17-30
9.?Wang Lei, Fu Cong, Fan Hongbo, Du Tingting, Dong Mei, Chen Yi, Jin Yi, Zhou Yi, Deng Min, Gu Aihua*, Jing Qing* Liu Tingxi, Zhou Yong*. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development 2013 Jul 1;140(13):2755-2764
10.?Gu Aihua*, Ji Guixiang, Yan Lifeng, Zhou Yong*. The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA Repair 2013 Dec 1;12(12):1094-1104
11.?Jing Changbin, Chen Yi, Dong Mei, Peng Xiaolan, Jia Xiaoe, Gao Lei, Ma Ke, Deng Min, Liu Tingxi, Zon LI, Zhu Jun*, Zhou Yi, Zhou Yong*, Liu Yijie. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Developmental Biology 2013 Feb 1;374(1):24-31
12.?Yan L#, Zhou Y#, Yu S, Ji G, Wang L, Liu W, Gu A. 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish. Exp Cell Res 2013;319(19):2954-2963
13.?Zhou Y#, Cashman TJ, Nevis K, Obregon P, Carney SA, Liu Y, Gu AH, Mosimann C, Sondalle S, Peterson R, Heideman W, Burns CE, Burns CG. Latent TGF-b binding protein 3 identifies a second heart field in zebrafish. Nature 2011;474:645-648 (Highlighted)
14.?Deacon DC, Nevis KR, Cashman TJ, Zhou Y, Zhao L, Washko D, Guner-Ataman B, Burns CG, Burns CE. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development 2010;137(11):1887-1896
15.?Zhou Y#, Ma C, Karmouch J, Katbi HA, Liu XJ. Antiapoptotic role for ornithine decarboxylase during oocyte maturation. Mol Cell Biol 2009 Apr;29(7):1786-1795
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