| Quantifying and interpreting biologically meaningful spatial signatures within tumor microenvironments |
| 論文作者 |
Jing, SY; Wang, HQ; Lin, P; Yuan, J; Tang, ZX; Li, H |
| 期刊/會議名稱 |
NPJ PRECISION ONCOLOGY |
| 論文年度 |
2025 |
| 論文類別 |
|
| 摘要 |
The tumor microenvironment (TME) plays a crucial role in orchestrating tumor cell behavior and cancer progression. Recent advances in spatial profiling technologies have uncovered novel spatial signatures, including univariate distribution patterns, bivariate spatial relationships, and higher-order structures. These signatures have the potential to revolutionize tumor mechanism and treatment. In this review, we summarize the current state of spatial signature research, highlighting computational methods to uncover spatially relevant biological significance. We discuss the impact of these advances on fundamental cancer biology and translational research, address current challenges and future research directions. |
| 卷 |
9 |
| 影響因子 |
8 |
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