| Oral microbiome diversity and diet quality in relation to mortality |
| 論文作者 |
Shen, J; Chen, H; Zhou, XF; Huang, QM; Garay, LG; Zhao, MJ; Qian, SJ; Zong, G; Yan, Y; Wang, XF; Wang, BH; Tonetti, M; Zheng, Y; Yuan, CZ |
| 期刊/會議名稱 |
JOURNAL OF CLINICAL PERIODONTOLOGY |
| 論文年度 |
2024 |
| 論文類別 |
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| 摘要 |
AimTo examine the independent and joint associations of oral microbiome diversity and diet quality with risks of all-cause and cause-specific mortality.Materials and MethodsWe included 7,055 eligible adults from the U.S. National Health and Nutrition Examination Survey (NHANES). Oral microbiome diversity was measured with alpha-diversity, including the Simpson Index, observed amplicon sequence variants (ASVs), Faith's phylogenetic diversity, and Shannon-Weiner index. Dietary quality was assessed using the Healthy Eating Index-2015 (HEI-2015). Cox proportional hazard models were used to assess the corresponding associations.ResultsDuring a mean follow-up of 9.0 years, we documented 382 all-cause deaths. We observed independent associations of oral microbiome diversity indices and dietary quality with all-cause mortality (hazard ratio [HR] = 0.63; 95% confidence interval [CI]: 0.49-0.82 for observed ASVs; HR = 0.68, 95% CI: 0.52-0.89 for HEI-2015). Jointly, participants with the highest tertiles of both oral microbiome diversity (in Simpson index) and HEI-2015 had the lowest hazard of mortality (HR = 0.37, 95% CI: 0.23-0.60). In addition, higher oral microbiome diversity was associated with lower risks of deaths from cardiometabolic disease and cancer.ConclusionsHigher oral microbiome alpha-diversity and diet quality were independently associated with lower risk of mortality. |
| 影響因子 |
5.8 |
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