向往的生活6-伊人伊人综合在线观看-午夜福利视频合集1000集第五季-偷窥 亚洲 色 国产 日韩-777午夜福利理论电影网-日韩经典欧美一区二区三区-久久se视频精品视频在线-亚洲A片一区日韩精品无码

Group 2 innate lymphoid cells (ILC2s) play crucial roles in mediating allergic inflammation. Recent studies also indicate their involvement in regulating tumor immunity. The tumor suppressor liver kinase B1 (LKB1) inactivating mutations are associated with a variety of human cancers; however, the role of LKB1 in ILC2 function and ILC2-mediated tumor immunity remains unknown. Here, we show that ablation of LKB1 in ILC2s results in an exhausted -like phenotype, which promotes the development of lung melanoma metastasis. Mechanistically, LKB1 deficiency leads to a marked increase in the expression of programmed cell death protein -1 (PD -1) in ILC2s through the activation of the nuclear factor of activated T cell pathway. Blockade of PD -1 can restore the effector functions of LKB1-deficient ILC2s, leading to enhanced antitumor immune responses in vivo . Together, our results reveal that LKB1 acts to restrain the exhausted state of ILC2 to maintain immune homeostasis and antitumor immunity.